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1994-08-20
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Document 0450
DOCN M9480450
TI Anaemia, blood transfusion practices, HIV and mortality among women of
reproductive age in western Kenya.
DT 9410
AU Zucker JR; Lackritz EM; Ruebush TK; Hightower AW; Adungosi JE; Were JB;
Campbell CC; Malaria Branch, Centers for Disease Control and
Prevention,; Public Health Service, US Department of Health and Human;
Services, Atlanta, GA 30333.
SO Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):173-6. Unique Identifier :
AIDSLINE MED/94310625
AB Severe anaemia among women in sub-Saharan Africa is frequently treated
with blood transfusions. The risk of transmission of human
immunodeficiency virus (HIV) through blood products has led to a
re-evaluation of the indications for transfusions. Prospective
surveillance of women admitted to a district hospital in western Kenya
was conducted from 1 December 1990 to 31 July 1991, for haemoglobin (Hb)
transfusion status, and outcome. Of the 2986 enrolled women (mean Hb
10.4 g/dL, SD +/- 2.6, median age 24.4 years), 6% were severely anaemic
(Hb < 6.0 g/dL). Severe anaemia was associated with a higher mortality
rate (10.7% vs. 1.4%, odds ratio (OR) = 8.2, 95% confidence interval
(CI) 2.6, 34.2) compared with women with Hb > or = 6.0 g/dL. Decreased
mortality rates in hospital were observed with increasing Hb values (OR
= 0.43, 95% CI 0.19, 0.98), but blood transfusions did not improve
survival in hospital (OR = 1.56, 95% CI 0.22, 11.03). The attributable
mortality due to HIV infection and severe anaemia was 75% and 31%,
respectively. Maternal/child health care services must include
prevention strategies for HIV transmission and the prevention,
recognition, and treatment of severe anaemia.
DE Adolescence Adult Anemia/BLOOD/*MORTALITY/THERAPY *Blood
Transfusion/STATISTICS & NUMER DATA Female Hemoglobins/ANALYSIS
Hospital Mortality Hospitalization Human HIV
Infections/BLOOD/*MORTALITY/TRANSMISSION Kenya/EPIDEMIOLOGY Logistic
Models Multivariate Analysis Pregnancy Pregnancy Complications,
Hematologic/BLOOD/MORTALITY Prospective Studies Support, Non-U.S.
Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).